VS Donnenberg, L Zimmerlin… - Cancer Stem Cells in …, 2011 - Springer Abstract There can be no cure for epithelial cancer until there is a significant therapeutic index that separates the most therapy-resistant cells within tumors, and the cells that mediate functions essential to life. The cancer stem cell paradigm explains tumor heterogeneity and has led ...
[HTML] from plos.orgSE Hensley, SR Das, JS Gibbs, AL Bailey… - PLoS One, 2011 - dx.plos.org Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody- ... Cited by 5 - Related articles - Cached - All 5 versions
L Parham, IL de Rivera, W Murillo… - AIDS research and …, 2011 - ncbi.nlm.nih.gov Antiretroviral therapy has had a great impact on the prevention of mother to child transmission (MTCT) of HIV-1. However, development of drug resistance, which could be subsequently transmitted to the child, is a major concern. In Honduras and Belize the prevalence of drug resistance ...
GJP Dijkgraaf, B Alicke, L Weinmann, T Januario… - Cancer research, 2011 - AACR Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC- ... Cited by 3 - Related articles - All 4 versions
SL Mitchell, N Seoudi, DCS Hutchison… - Thorax, 2011 - thorax.bmj.com Undiagnosed chronic obstructive pulmonary disease (COPD) is a major public health issue, as it leads to patients missing out on appro- priate preventive and therapeutic inter- ventions.1e3 The ratio of diagnosed/predicted COPD prevalence differs widely between ... Cited by 1 - Related articles - All 3 versions
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