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D Demirbas, O Ceyhan, AR Wyman… - … as Drug Targets, 2011 - Springer
Abstract Fission yeast strains have been engineered so that their growth behavior reflects the
activity of heterologous cyclic nucleotide phosphodiesterases (PDEs). These strains can be used
in High-Throughput Screens (HTSs) for PDE inhibitors that possess “drug-like” ...
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GW Hoyle, W Chang, J Chen… - American Journal of …, 2011 - Am Thoracic Soc
... The Type 4 Phosphodiesterase Inhibitor Rolipram Ameliorates Chlorine-Induced
Acute Lung Injury In Mice , W ... Rolipram is an inhibitor of type 4 phosphodiesterase
and increases cAMP levels by inhibiting cAMP hydrolysis. The ...
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[HTML] from plos.orgM Kiebala… - PloS one, 2011 - dx.plos.org
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND)
occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator
of transcription (Tat), in the central nervous system (CNS). Given the need for novel ...
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[PDF] from biomedcentral.comR Lewis, J Connor, J Teerlink, J Murphy, L Cooper… - Trials, 2011 - biomedcentral.com
Background: Claudication secondary to peripheral artery disease (PAD) is associated with substantial
functional impairment. Phosphodiesterase (PDE) inhibitors have been shown to increase walking
performance in these patients. K- 134 is a selective PDE 3 inhibitor being developed as a ...
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RA Samangaya, M Wareing… - Hypertension in …, 2011 - informahealthcare.com
Objective. To determine if the phosphodiesterase type 5 inhibitor, sildenafil citrate improves
endothelial-dependent relaxation of small arteries from women with preeclampsia. Methods.
Myometrial and omental biopsies were taken from women participating in a randomized ...
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