H Greulich… - Trends in Molecular Medicine, 2011 - Elsevier ... Fibroblast growth factor receptors (FGFRs) play diverse roles in the control of cell proliferation ... Many of these somatic mutations are gain-of-function and oncogenic and create ... in preclinical models has further substantiated genomically altered FGFR as a therapeutic target in ... Related articles - All 2 versions
AS Tsao, W Wei, E Kuhn, L Spencer… - Clinical lung …, 2011 - ncbi.nlm.nih.gov ... Immunohistochemical Overexpression of Platelet-Derived Growth Factor Receptor-Beta (PDGFR-β) is Associated With ... high PDGFR-β IHC expression and gene copy number gain in sarcomatoid ... are warranted to determine whether PDGFR-β is a feasible therapeutic target in ... All 2 versions
A Armuzzi, D Pugliese - Nature Reviews Gastroenterology and …, 2011 - nature.com ... Adalimumab is an anti-tumor necrosis factor (TNF) agent that has been shown to be effective for both inducing and maintaining remission in moderately to severely active Crohn's disease. ... Therefore, therapeuticgain of adalimumab over placebo was only 9.3%. ... Related articles - All 3 versions
B Robinson, J Zhang, J Thumma… - NDT …, 2011 - ndtplus.oxfordjournals.org ... In this population, logistic regression analysis identified previous infection by MRSa as the only factor associated with a higher risk of colonization. CONCLUSIONS: In this population a significant prevalence of MRSa colonization was found. ...
[PDF] from eurobonet.euA Shalaby, N Presneau, H Ye… - The Journal of …, 2011 - Wiley Online Library ... such as activation of fibroblastic growth factor receptors or insulin-like growth factor 1 receptor ... These data suggest that gain in HER2 copy number increases sensitivity to gefitinib of EGFR FISH ... In theory, a similar therapeutic advantage might be expected to be afforded to the 17 ... Cited by 3 - Related articles - All 5 versions
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