B Herzog, C Pellet-Many, G Britton… - Molecular Biology of …, 2011 - Am Soc Cell Biol In endothelial cells, Neuropilin-1 (NRP1) binds VEGF-A and is thought to act as a coreceptor for KDR by associating with KDR and enhancing VEGF signalling. Here we report mutations in the NRP1 b1 domain (Y297A and D320A), which result in complete loss of VEGF ... All 3 versions
E Allen, IB Walters… - Clinical Cancer Research, 2011 - AACR Experimental Design: An anti-VEGFR2 monoclonal antibody (DC101), an inhibitor of FGF signaling (FGF ligand trap), sorafenib, and brivanib were comparatively evaluated in first-line monotherapy in short and longer term fixed endpoint intervention trials in the RIP-Tag2 mouse model of ... Cited by 2
E Allen, I Walters… - Clinical Cancer Research, 2011 - AACR Page 1. Published OnlineFirst May 27, 2011. Clin Cancer Res Elizabeth Allen, Ian Walters and Douglas Hanahan evasive/adaptive resistance to VEGF inhibition 2nd line against mouse PNET tumors developing Brivanib, an FGF/VEGF inhibitor, is differentially active 1st vs. ... Related articles - All 2 versions
AE Esquibies, A Bazzy-Asaad… - American Journal of …, 2011 - Am Thoracic Soc Yale University, New Haven, CT, Yale School of Medicine, New Haven 1 2 ... Corresponding author's email: americo.esquibies@yale.edu ... VEGF is regulated by oxygen and plays an important role in vascular development and epithelial cell morphogenesis. During hyperoxia, VEGF ... All 3 versions
L Farkas, M Greve, D Farkas… - American Journal of …, 2011 - Am Thoracic Soc Pulmonary arterial hypertension (PAH) is a deadly disease with poor prognosis, histologically characterized by Introduction: angioproliferative lesions with hyperproliferative, apoptosis-resistant endothelial cells (ECs). Our group has previously shown that inhibition of vascular ... All 3 versions
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