R Rappuoli… - Nature, 2011 - nature.com Acquired immune deficiency syndrome (AIDS), malaria and tuberculosis collectively cause more than five million deaths per year, but have nonetheless eluded conventional vaccine development; for this reason they represent one of the major global public health ... Cited by 2 - Related articles - All 3 versions
SHE Kaufmann - Nature Medicine, 2011 - nature.com New tuberculosis vaccines are urgently needed to reduce the threat of this devastating disease. An approach consisting of a fusion protein of three tuberculosis antigens provides significant protection in before- and after-exposure challenge mouse models, representing a crucial ...
[HTML] from nih.govJ Curtis, L Kopanitsa, E Stebbings, A Speirs… - Tuberculosis, 2011 - Elsevier Immunoregulatory eicosanoids have been implicated in protection from mycobacterial infection in cell and animal models. Recently, a study of the zebrafish embryo demonstrated that mutants of the lta4h gene, which encodes the leukotriene A4 hydrolase (LTA4H) enzyme of the ... Related articles - All 4 versions
M Ruhwald, J Dominguez, I Latorre, M Losi… - Tuberculosis, 2011 - Elsevier IP-10 and QFT-IT had comparable accuracy. Sensitivity was 81% and 84% with a specificity of 97% and 100%, respectively. Combining IP-10 and QFT-IT improved sensitivity to 87% (p < 0.0005), with a specificity of 97%. T-SPOT.TB was more sensitive than QFT-IT, but not ... Related articles - All 3 versions
CM Bark, A Okwera, ML Joloba, BA Thiel… - Tuberculosis, 2011 - Elsevier Testing new drugs is critical to improving the treatment of tuberculosis. Quantitative cultures of Mycobacterium tuberculosis on solid media have been used in Phase 1 and 2 trials, but are time and resource intensive. Time to detection (TTD) of growth of M. tuberculosis in automated ... Cited by 1 - Related articles - All 3 versions
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