T Hiekkalinna, AA Schäffer, B Lambert… - Human …, 2011 - content.karger.com A decade ago, there was widespread enthusiasm for the prospects of genome-wide association studies to identify common variants related to common chronic diseases using samples of unrelated individuals from populations. Although technological advancements allow us to query ...
JL St Sauver, BR Grossardt, BP Yawn… - American Journal of …, 2011 - Oxford Univ Press The Rochester Epidemiology Project (REP) is a unique research infrastructure in which the medical records of virtually all persons residing in Olmsted County, Minnesota, for over 40 years have been linked and archived. In the present article, the authors describe how the REP links ... Cited by 2 - Related articles - All 4 versions
FA Wright, LJ Strug, VK Doshi, CW Commander… - Nature genetics, 2011 - nature.com A combined genome-wide association and linkage study was used to identify loci causing variation in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10 −8 ) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The ... Cited by 1 - Related articles - All 4 versions
LJ Palmer, NJ Timpson, DM Evans… - An Introduction to …, 2011 - books.google.com FOUR mapping complex disease genes using linkage disequilibrium and genome- wide association scans Lyle J. Palmer, Nicholas J. Timpson, David M. Evans, George Davey Smith, Lon R. Cardon Summary Remarkable advances have occurred recently in our ability to detect genetic ... Related articles
KE Wickliffe, S Lorenz, DE Wemmer, J Kuriyan… - Cell, 2011 - Elsevier Ubiquitin chains of different topologies trigger distinct functional consequences, including protein degradation and reorganization of complexes. The assembly of most ubiquitin chains is promoted by E2s, yet how these enzymes achieve linkage specificity is poorly understood. We have ... Cited by 5 - Related articles - All 3 versions
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