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T Hiekkalinna, AA Schäffer, B Lambert… - Human …, 2011 - content.karger.com
A decade ago, there was widespread enthusiasm for the prospects of genome-wide association
studies to identify common variants related to common chronic diseases using samples of unrelated
individuals from populations. Although technological advancements allow us to query ...
JL St Sauver, BR Grossardt, BP Yawn… - American Journal of …, 2011 - Oxford Univ Press
The Rochester Epidemiology Project (REP) is a unique research infrastructure in which the medical
records of virtually all persons residing in Olmsted County, Minnesota, for over 40 years have
been linked and archived. In the present article, the authors describe how the REP links ...
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FA Wright, LJ Strug, VK Doshi, CW Commander… - Nature genetics, 2011 - nature.com
A combined genome-wide association and linkage study was used to identify loci causing variation
in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10
−8 ) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The ...
Cited by 1 - Related articles - All 4 versions
LJ Palmer, NJ Timpson, DM Evans… - An Introduction to …, 2011 - books.google.com
FOUR mapping complex disease genes using linkage disequilibrium and genome- wide association
scans Lyle J. Palmer, Nicholas J. Timpson, David M. Evans, George Davey Smith, Lon R. Cardon
Summary Remarkable advances have occurred recently in our ability to detect genetic ...
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KE Wickliffe, S Lorenz, DE Wemmer, J Kuriyan… - Cell, 2011 - Elsevier
Ubiquitin chains of different topologies trigger distinct functional consequences, including protein
degradation and reorganization of complexes. The assembly of most ubiquitin chains is promoted
by E2s, yet how these enzymes achieve linkage specificity is poorly understood. We have ...
Cited by 5 - Related articles - All 3 versions

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