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Q Xie, R Wondergem, Y Shen… - Proceedings of the …, 2011 - National Acad Sciences
Geldanamycin and its derivative 17AAG [17-(Allylamino)-17-demethoxygeldanamycin,
telatinib] bind selectively to the Hsp90 chaperone protein and inhibit its function. We discovered
that these drugs associate with mitochondria, specifically to the mitochondrial membrane ...
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HG Floss, TW Yu… - ChemInform, 2011 - Wiley Online Library
... Reviews. ChemInform Abstract: The Biosynthesis of 3-Amino-5-hydroxybenzoic Acid (AHBA),
the Precursor of mC 7 N Units in Ansamycin and Mitomycin Antibiotics. Heinz G. Floss,;
Tin-Wein Yu,; Kenji Arakawa. Article first published online: 21 APR 2011. ...
MC Wilson, SJ Nam, TAM Gulder… - Journal of the …, 2011 - ACS Publications
Reported is the structure and biosynthesis of ansalactam A, an ansamycin class polyketide produced
by an unusual modification of the polyketide pathway. This new metabolite, produced by a marine
sediment-derived bacterium of the genus Streptomyces, possesses a novel spiro γ-lactam ...
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K Pyta… - Journal of Mass Spectrometry, 2011 - Wiley Online Library
The modern MS, based on laser desorption and electrospray 'soft' ionisation methods, is a powerful
tool for identification, characterisation and quantitative determination of traces of structurally complex
therapeutics in biological materials and investigation of their metabolites.13–15 ...
JR Porter… - EP Patent 2,348,845, 2011 - freepatentsonline.com
... Title: ANSAMYCIN HYDROQUINONE COMPOSITIONS. Document Type and Number:
European Patent Application EP2348845 Kind Code: A1. Inventors: Porter, James
R. (39 Wilson Pond Road, Rowley MA 01969, US) Puri ...
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