Q Xie, R Wondergem, Y Shen… - Proceedings of the …, 2011 - National Acad Sciences Geldanamycin and its derivative 17AAG [17-(Allylamino)-17-demethoxygeldanamycin, telatinib] bind selectively to the Hsp90 chaperone protein and inhibit its function. We discovered that these drugs associate with mitochondria, specifically to the mitochondrial membrane ... Related articles - All 4 versions
HG Floss, TW Yu… - ChemInform, 2011 - Wiley Online Library ... Reviews. ChemInform Abstract: The Biosynthesis of 3-Amino-5-hydroxybenzoic Acid (AHBA), the Precursor of mC 7 N Units in Ansamycin and Mitomycin Antibiotics. Heinz G. Floss,; Tin-Wein Yu,; Kenji Arakawa. Article first published online: 21 APR 2011. ...
MC Wilson, SJ Nam, TAM Gulder… - Journal of the …, 2011 - ACS Publications Reported is the structure and biosynthesis of ansalactam A, an ansamycin class polyketide produced by an unusual modification of the polyketide pathway. This new metabolite, produced by a marine sediment-derived bacterium of the genus Streptomyces, possesses a novel spiro γ-lactam ... Related articles - All 4 versions
K Pyta… - Journal of Mass Spectrometry, 2011 - Wiley Online Library The modern MS, based on laser desorption and electrospray 'soft' ionisation methods, is a powerful tool for identification, characterisation and quantitative determination of traces of structurally complex therapeutics in biological materials and investigation of their metabolites.13–15 ...
JR Porter… - EP Patent 2,348,845, 2011 - freepatentsonline.com ... Title: ANSAMYCIN HYDROQUINONE COMPOSITIONS. Document Type and Number: European Patent Application EP2348845 Kind Code: A1. Inventors: Porter, James R. (39 Wilson Pond Road, Rowley MA 01969, US) Puri ... Cached
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