Y Maman, A Blancher, J Benichou… - Journal of …, 2011 - Am Soc Microbiol ... Reduction of CD8 + T cell epitopes is one of the common strategies used for this purpose. Hepatitis B virus (HBV), a member of the Hepadnaviridae family, has four open reading frames, with about 50% overlap between the genes they encode. ... Related articles - All 4 versions