K Kuhlbrodt, PC Janiesch, É Kevei, A Segref… - Nature Cell …, 2011 - nature.com Protein ubiquitylation is a key post-translational control mechanism contributing to different physiological processes, such as signal transduction and ageing. The size and linkage of a ubiquitin chain, which determines whether a substrate is efficiently targeted for proteasomal ... Cited by 6 - Related articles - All 3 versions
TM Durcan, M Kontogiannea… - Human molecular …, 2011 - Oxford Univ Press Machado–Joseph disease (MJD), the most common dominantly inherited ataxia worldwide, is caused by a polyglutamine (polyQ) expansion in the deubiquitinating (DUB) enzyme ataxin-3. Interestingly, MJD can present clinically with features of Parkinsonism. In this ... Cited by 3 - Related articles - All 5 versions
YC Lo, KK Liao, YC Lee… - Journal of Medical …, 2011 - jmedicalcasereports.com A 29-year-old man (Han Chinese, Hoklo) with Machado-Joseph disease experienced severe chronic pain in both feet, cutaneous thermal change, thermal hypersensitivity, focal edema, and sweating and had a history of bone fracture. These symptoms are compatible with a ... Cached - All 3 versions
I Nascimento-Ferreira, T Santos-Ferreira… - Brain, 2011 - Oxford Univ Press Machado–Joseph disease, also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 misfolding, intracellular accumulation of aggregates and neuronal degeneration. Here we ... Related articles - All 4 versions
Y Horimoto, M Matsumoto, H Akatsu, A Kojima… - Journal of …, 2011 - Springer Abstract To disclose the neuropathological progression course of Machado–Joseph disease (MJD), magnetic res- onance imaging (MRI) findings of six genetically con- firmed MJD cases (four males and two females, including an autopsied female, all unrelated to one another) ... Cited by 1 - Related articles - All 2 versions
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