G Lappin, M Seymour, G Young, D Higton… - Bioanalysis, 2011 - Future Science A technique has emerged in the past few years that has enabled a drug's intravenous pharmacokinetics to be readily obtained in humans without having to conduct extensive toxicology studies by this route of administration or expend protracted effort in formulation. The technique involves ... Cited by 2 - Related articles - All 3 versions
G Lappin, M Seymour, G Young, D Higton… - Bioanalysis, 2011 - Future Science The absolute bioavailability, clearance and volume of distribution of a drug can be investigated by administering a very low dose of the 14 C-drug intravenously along with a therapeutic nonlabeled dose by the extravascular route (typically orally). The total drug concentration is ... Cited by 1 - Related articles - All 3 versions
J Stangier, H Stähle, K Rathgen… - The Journal of …, 2011 - jcp.sagepub.com ... before administration of the next dose (Cpre,ss), mean resi- dence time of the analyte in the body at steady state after oral administration (MRTpo,ss), and apparent vol- ume of distribution during the terminal phase λz at steady state following extravascularadministration (Vz/Fss ...
[CITATION] Pharmacokinetics and Pharmacodynamics of Antimicrobials
LL Estes - Mayo Clinic Infectious Diseases Board …, 2011 - Oxford University Press, USA Related articles - All 2 versions
C Friedrich, A Ring, T Brand, R Sennewald… - European journal of …, 2011 - Springer ... in plasma following extra- vascularadministration at steady-state (CL/Fss); the amount of analyte eliminated from urine over the time interval t1–t2 at steady-state (Aet1Àt2,ss); the apparent vol- ume of distribution during the terminal phase kz following an extravascular dose at ... Cited by 6 - Related articles - All 4 versions