K Maeda, J Takano, Y Ikeda, T Fujita… - Clinical Pharmacology …, 2011 - nature.com Microdosing studies are effective in enabling the early identification of the pharmacokinetic properties of compounds administered to humans. However, the nonlinearity of the pharmacokinetics between microdose and therapeutic dose, attributable to the saturation of metabolic enzymes and ... All 3 versions
C Landersdorfer, C Kirkpatrick, J Bulitta… - 2006 AAPS Annual …, 2011 - aapsj.org Population Pharmacokinetics of Piperacillin at Two Dose Levels: Influence of Nonlinear Pharmacokinetics on the Pharmacodynamic Profile C. Landersdorfer 1, C. Kirkpatrick 2, J. Bulitta 1, M. Kinzig-Schippers 1, U. Holzgrabe 3, G. Drusano 4, F. Sörgel 1 1 IBMP, Nürnberg ... View as HTML - All 2 versions
HW Shen, XL Jiang… - Drug Metabolism and Disposition, 2011 - ASPET 5-Methoxy-N,N,-dimethyltryptamine (5-MeO-DMT), an abused serotonergic indolealkylamine drug, was placed into Schedule I controlled substance status in the United States as of January 19, 2011. In previous studies, we have shown the impact of monoamine oxidase A and ... Related articles - All 3 versions
JQ Dong, DH Salinger, CJ Endres… - … pharmacokinetics, 2011 - ingentaconnect.com ... A model for projected mean human pharmacokinetics was determined by assuming the ... For the Michaelis-Menten non- linear elimination parameters, maximum rate (Vmax) was scaled ... two-compartment pharmacokinetic model with parallel linear and nonlinear elimination from ... Related articles - All 4 versions
KB Scheidweiler, B Ladenheim… - Journal of Analytical …, 2011 - ingentaconnect.com ... MDMA displays nonlinearpharmacokinetics in human (14,15), squirrel monkey (16), and rat (17,18) MDMA dose-escalation studies, yielding higher maximum MDMA plasma concentrations (Cmax) and area under the curves (AUCs) than predicted. ...
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