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S Bhaumik, TV Sekar, J Depuy, J Klimash… - Gene Therapy, 2011 - nature.com
Gene-directed enzyme prodrug therapy (GDEPT) is a promising and emerging strategy that attempts
to limit the systemic toxicity inherent to cancer chemotherapy by means of tumor-targeted delivery
and expression of an exogenous gene whose product converts nontoxic prodrug(s) into ...
[HTML] from pnas.orgS Dhar, N Kolishetti, SJ Lippard… - Proceedings of the …, 2011 - National Acad Sciences
Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach
to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of
all cancers today. Using prostate cancer (PCa) as a model disease, we previously ...
Cited by 9 - Related articles - All 6 versions
KN Ganjoo, LD Cranmer, JE Butrynski… - Oncology, 2011 - content.karger.com
Purpose: The purpose of this study was to determine the dose-limiting toxicities (DLT), maximum
tolerated dose (MTD), safety, pharmacokinetics and preliminary activity of TH-302, a
hypoxia-activated prodrug, in combination with doxorubicin in patients with advanced soft ...
Related articles - All 2 versions
HD Thomas, LZ Wang, C Roche, J Bentley… - European Journal of …, 2011 - Elsevier
To facilitate the evaluation of CDK2 (cyclin-dependent kinase 2) as a cancer target, the in vitro
and in vivo properties of NU6102 (O 6 -cyclohexylmethyl-2-(4′-sulphamoylanilino)purine) and
a water soluble prodrug (NU6301) were investigated. NU6102 selectively inhibited the ...
Related articles - All 3 versions
S Lowe, R Dean, B Ackermann, K Jackson… - …, 2011 - Springer
Abstract Rationale Accumulating evidence suggests that the primary symptoms of schizophrenia
may be associated with altered central glutamate transmission. LY2140023 monohydrate is the
methionine prodrug of the selective mGlu2/3 receptor agonist LY404039 and is currently ...

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