F Muller, J Konig, H Glaeser, I Schmidt… - Antimicrobial Agents …, 2011 - Am Soc Microbiol The antimalarial drug chloroquine is eliminated to a significant extent by renal tubular secretion. The molecular mechanism of renal chloroquine secretion remains unknown. We hypothesized that organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 ... Related articles - All 3 versions
T Watanabe, H Kusuhara, T Watanabe… - Drug Metabolism and …, 2011 - ASPET The present study investigated prediction of the overall renal tubular secretion and hepatic clearances of anionic drugs based on in vitro transport studies. The saturable uptake of eight drugs, most of which were OAT3 substrates (rosuvastatin, pravastatin, pitavastatin, valsartan, ... Related articles - All 3 versions
J Lowenstein - The FASEB Journal, 2011 - FASEB ... moved into fresh water, glomerular filtration evolved as the mechanism by which fish maintained osmotic integrity and the tubules acquired transporters which reclaimed the filtered glucose and other “valuable substances,” but these fish still relied on tubularsecretion to dispose ... Related articles - All 2 versions
F Ranchon, N Vantard, A Gouraud… - …, 2011 - content.karger.com ... toxicity has been demonstrated to be directly related to methotrexate plasma concentrations, exposure time and the area under the curve [2]. Methotrexate is eliminated almost entirely in unchanged form in the urine by passive glomerular filtration and active tubularsecretion. ... Related articles - All 3 versions
ML Patel… - BMJ Case Reports, 2011 - casereports.bmj.com ... impaired renal function in hypothyroidism is multifactorial, the reduction in GFR due to the lower cardiac output and renal blood flow is likely to be the predominant mechanism.1 It has also been suggested that thyroxine may mediate tubularsecretion of creatinine.2 Furthermore ... Related articles - All 2 versions
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