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D Egan, J Kim, RJ Shaw… - Autophagy, 2011 - ncbi.nlm.nih.gov
The serine/threonine kinase ULK1 is a mammalian homolog of Atg1, part of the Atg1 kinase
complex, which is the most upstream component of the core autophagy machinery conserved
from yeast to mammals. In budding yeast, activity of the Atg1 kinase complex is inhibited ...
Cited by 1 - All 5 versions
E Moussay, T Kaoma, J Baginska, A Muller… - Autophagy, 2011 - ncbi.nlm.nih.gov
While the autophagic process is mainly regulated at the post-translational level, a growing body
of evidence suggests that autophagy might also be regulated at the transcriptional level. The
identification of transcription factors involved in the regulation of autophagy genes has ...
All 5 versions
M Graef… - Autophagy, 2011 - ncbi.nlm.nih.gov
Understanding the functional relationship between mitochondria and autophagy is critical for
understanding the molecular mechanisms underlying ageing and neurodegeneration. Autophagy
functions in both cellular homeostasis and in quality control in the selective removal of ...
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MK McCoy… - Autophagy, 2011 - ncbi.nlm.nih.gov
The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson
disease. Mutations in the parkin, PINK1, and DJ-1 genes all result in recessive
parkinsonism. Although the protein products of these genes have not been fully ...
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H Li, P Wang, J Yu… - Autophagy, 2011 - ncbi.nlm.nih.gov
Autophagy is often found in apoptosis-defective cancer cells and contributes to chemotherapy
resistance. However, it is far from clear how the coordination of apoptosis and autophagy determines
sensitivity of cancer cells to chemotherapy. Our recent study showed that Beclin 1, a key ...
All 5 versions

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