[PDF] from nih.govS John, PJ Sabo, RE Thurman, MH Sung… - Nature genetics, 2011 - nature.com Development, differentiation and response to environmental stimuli are characterized by sequential changes in cellular state initiated by the de novo binding of regulated transcriptional factors to their cognate genomic sites 1, 2, 3 . The mechanism whereby a given regulatory factor ... Cited by 18 - Related articles - All 5 versions
[HTML] from nih.govR Patel, M Patel, R Tsai, V Lin… - The Journal of …, 2011 - ncbi.nlm.nih.gov Although widely prescribed for their potent antiinflammatory actions, glucocorticoid drugs (eg, dexamethasone) cause undesirable side effects that are features of the metabolic syndrome, including hyperglycemia, fatty liver, insulin resistance, and type II diabetes. ... Cited by 2 - Related articles - All 4 versions
M Surjit, KP Ganti, A Mukherji, T Ye, G Hua… - Cell, 2011 - Elsevier The glucocorticoid (GC) receptor (GR), when liganded to GC, activates transcription through direct binding to simple (+)GRE DNA binding sequences (DBS). GC-induced direct repression via GR binding to complex “negative” GREs (nGREs) has been reported. However, GR- ... Cited by 1 - All 2 versions
F Ros-Bernal, S Hunot, MT Herrero… - Proceedings of the …, 2011 - National Acad Sciences Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non–cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory ... Cited by 1 - Related articles - All 4 versions
M Gutièrrez-Mecinas, AF Trollope… - Proceedings of the …, 2011 - National Acad Sciences Stressful events are known to have a long-term impact on future behavioral stress responses. Previous studies suggested that both glucocorticoid hormones and glutamate acting via glucocorticoid receptors (GRs) and N-methyl d-aspartate (NMDA) receptors, ...